Adaptive Inter-Region Attention Network for Multimodal Brain Tumor Analysis

Authors

  • V.Indhumathi, Vishnupriyan A, Vicky Kumar, Thirupathi C, Theja S Department of CSE, Gnanamani College of Technology, Namakkal, Tamil Nadu, India Author

DOI:

https://doi.org/10.15662/IJEETR.2026.0802387

Keywords:

YOLOv8, Convolutional Neural Networks (CNNs), Hybrid Model, Tumor Staging

Abstract

Functional Magnetic Resonance Imaging (fMRI) provides critical insights into dynamic brain activity and connectivity patterns, enabling the study of neural functions over time. Traditional clustering methods, such as Topological Data Analysis (TDA), are limited to grouping brain networks and cannot accurately detect or classify active regions or abnormalities like tumors. Manual interpretation of MRI and fMRI data is time-consuming, prone to human error, and often inconsistent across multi-site datasets. To overcome these challenges, the proposed system introduces a hybrid YOLOv8 and Convolutional Neural Network (CNN) framework for automated detection, localization, classification, and staging of brain tumors along with analysis of normal brain activity. YOLOv8 precisely detects and localizes active brain regions and tumor regions in MRI and fMRI-derived maps, generating bounding boxes and confidence scores. The CNN extracts deep spatial and temporal features from these detected regions, enabling accurate classification of brain states and determination of tumor stage. The hybrid approach combines object detection with deep feature learning, capturing both spatial location and functional significance of regions. The system is trained on multi-site, multi-modal datasets to ensure robustness against scanner variability and non-neural artifacts. Experimental results show that the framework achieves high accuracy in both brain activity analysis and tumor detection and staging. This automated method reduces dependence on manual interpretation, providing faster, more reliable, and interpretable insights. It supports early diagnosis, treatment planning, and monitoring of brain tumors. By integrating YOLOv8 localization with CNN feature extraction, the system offers a comprehensive and scalable solution for brain network analysis and clinical applications. Overall, this approach represents a significant advancement in deep learning–based neuroimaging for automated brain activity and tumor assessment.

References

1. Kumar and R. Sharma, “Real-Time Brain Tumor Detection Using Deep Learning,” IEEE Access, vol. 9, pp. 12345–12355, 2021.

2. S. Gupta and P. Jain, “Automated Brain MRI Analysis Using YOLO and CNN,” International Journal of Advanced Computer Science, vol. 12, no. 4, pp. 67–75, 2021.

3. M. Roy and K. Singh, “Hybrid Deep Learning Approaches for fMRI Analysis,” IEEE Transactions on Medical Imaging, vol. 40, no. 2, pp. 567–578, 2021.

4. H. Lee et al., “Dynamic Functional Connectivity Analysis Using Deep Learning,” Neurocomputing, vol. 452, pp. 123–136, 2021.

5. Y. Zhang and L. Wang, “YOLO-Based Tumor Detection in MRI Images,” Journal of Healthcare Engineering, vol. 2022, Article ID 9876543, 2022.

6. P. Mehta and R. Verma, “Automated Brain Tumor Classification Using CNN,” Computers in Biology and Medicine, vol. 142, pp. 105–115, 2022.

7. Choi et al., “Deep Learning for Multi-Site fMRI Data Analysis,” IEEE Access, vol. 10, pp. 45678–45690, 2022.

8. S. Gupta, P. Sharma, and K. Roy, “YOLOv8 and CNN for Brain Abnormality Detection,” Biomedical Signal Processing and Control, vol. 79, pp. 103–115, 2023.

9. R. Sharma and A. Kumar, “Automated Brain Activity Classification Using Hybrid Deep Learning Models,” IEEE Journal of Biomedical and Health Informatics, vol. 27, no. 6, pp. 1400–1412, 2023.

10. C.Nagarajan and M.Madheswaran - ‘Stability Analysis of Series Parallel Resonant Converter with Fuzzy Logic Controller Using State Space Techniques’- Taylor &Francis, Electric Power Components and Systems, Vol.39 (8), pp.780-793, May 2011. DOI: 10.1080/15325008.2010.541746

11. C.Nagarajan and M.Madheswaran - ‘Experimental verification and stability state space analysis of CLL-T Series Parallel Resonant Converter’ - Journal of Electrical Engineering, Vol.63 (6), pp.365-372, Dec.2012. DOI: 10.2478/v10187-012-0054-2

12. C.Nagarajan and M.Madheswaran - ‘Performance Analysis of LCL-T Resonant Converter with Fuzzy/PID Using State Space Analysis’- Springer, Electrical Engineering, Vol.93 (3), pp.167-178, September 2011. DOI 10.1007/s00202-011-0203-9

13. S.Tamilselvi, R.Prakash, C.Nagarajan,“Solar System Integrated Smart Grid Utilizing Hybrid Coot-Genetic Algorithm Optimized ANN Controller” Iranian Journal Of Science And Technology-Transactions Of Electrical Engineering, DOI10.1007/s40998-025-00917-z,2025

14. S.Tamilselvi, R.Prakash, C.Nagarajan,“ Adaptive sliding mode control of multilevel grid-connected inverters using reinforcement learning for enhanced LVRT performance” Electric Power Systems Research 253 (2026) 112428, doi.org/10.1016/j.epsr.2025.112428

15. S.Thirunavukkarasu, C. Nagarajan, 2024, “Performance Investigation on OCF and SCF study in BLDC machine using FTANN Controller," Journal of Electrical Engineering And Technology, Volume 20, pages 2675–2688, (2025), doi.org/10.1007/s42835-024-02126-w

16. Nagarajan, M.Madheswaran and D.Ramasubramanian- ‘Development of DSP based Robust Control Method for General Resonant Converter Topologies using Transfer Function Model’- Acta Electrotechnica et Informatica Journal , Vol.13 (2), pp.18-31,April-June.2013, DOI: 10.2478/aeei-2013-0025.

17. C.Nagarajan and M.Madheswaran - ‘DSP Based Fuzzy Controller for Series Parallel Resonant converter’- Springer, Frontiers of Electrical and Electronic Engineering, Vol. 7(4), pp. 438-446, Dec.12. DOI 10.1007/s11460-012-0212-0.

18. C.Nagarajan and M.Madheswaran - ‘Experimental Study and steady state stability analysis of CLL-T Series Parallel Resonant Converter with Fuzzy controller using State Space Analysis’- Iranian Journal of Electrical & Electronic Engineering, Vol.8 (3), pp.259-267, September 2012.

19. C.Nagarajan and M.Madheswaran, “Analysis and Simulation of LCL Series Resonant Full Bridge Converter Using PWM Technique with Load Independent Operation” has been presented in ICTES’08, a IEEE / IET International Conference organized by M.G.R.University, Chennai.Vol.no.1, pp.190-195, Dec.2007

20. Suganthi Mullainathan, Ramesh Natarajan, “An SPSS and CNN modelling based quality assessment using ceramic materials and membrane filtration techniques”, Revista Materia (Rio J.) Vol. 30, 2025, DOI: https://doi.org/10.1590/1517-7076-RMAT-2024-0721

21. M Suganthi, N Ramesh, “Treatment of water using natural zeolite as membrane filter”, Journal of Environmental Protection and Ecology, Volume 23, Issue 2, pp: 520-530,2022

22. L. Chen, Y. Li, and M. Wang, “Deep Learning-Based MRI Analysis for Tumor Detection and Staging,” Computers in Biology and Medicine, vol. 156, Article 106623, 2023.

23. Gopinathan, V. R. (2024). Real-Time Fault-Tolerant Multi-Cloud Database Architectures for High Availability Applications. International Journal of Future Innovative Science and Technology (IJFIST), 7(4), 13148.

24. Chandra, S., Rengarajan, A., Sahoo, G. S., & Sharma, S. (2023, December). Identifying Neuronal Damage and Plasticity by Analyzing Changes in Diffusion Tensor Imaging. In International Conference on Data Science, Machine Learning and Applications (pp. 433-438). Singapore: Springer Nature Singapore.

25. Sugumar, R. (2025). Federated AI in Offline-First Mobile Health Architectures for Privacy-Preserving Clinical Intelligence. International Journal of Science, Research and Technology, 8(4), 14589-14600.

26. Murugeshwari, B., Rajalakshmi, S., & Sudharson, K. (2023). Hybrid Approach for Privacy Enhancement in Data Mining Using Arbitrariness and Perturbation. Computer Systems Science & Engineering, 44(3).

27. Pandey, V. K., Mishra, S., Rengarajan, A., Savita, & Roomi, M. M. (2024, March). Enhancing Weather Forecasting with Machine Learning Techniques. In International Conference on Renewable Power (pp. 147-156). Singapore: Springer Nature Singapore.

28. Soundappan, S. J. (2025). Next Generation AI Enabled Holistic Cognitive Platform for Secure Cloud Network Intelligence Enterprise Systems and Digital Trust Optimization. International Journal of Computer Technology and Electronics Communication, 8(5), 11534-11542.

29. Mathew, A. (2022). Leveraging Big Data Analytics to Power AI and ML (Machine Learning) Automation. Educational Research (IJMCER), 4(5), 131-134.

30. Sugumar, R. (2024). AI-Augmented Quality Engineering for Performance Optimization and Test Orchestration in Distributed Systems. International Journal of Science, Research and Technology, 7(5), 12835-12846.

31. Akila, R. (2024). A deep reinforcement learning approach for optimizing inventory management in the agri-food supply chain. J. Electrical Systems, 20(4s), 2238-2247.

32. Mahendran, M., Anbazhagan, K., Pavithran, G., Nivas, A., & Pandey, S. D. (2022). Earthquake Damage Prediction using Machine Learning. Grenze International Journal of Engineering & Technology (GIJET), 8(1).

33. Gopinathan, V. R. (2025). Enterprise AI Frameworks for Financial Data Engineering Behavioural Analytics and Intelligent Cloud Solutions. International Journal of Research Publications in Engineering, Technology and Management (IJRPETM), 8(4), 12499-12506.

34. Kondalsamy, P., & Kaliappan, K. (2025). An Optimal Prediction of Leaf Disease Based on Hybrid Deep Learnings and Metaheuristic Technique. Traitement du Signal, 42(1), 363.

35. Deivendran, P., Babu, P. S., Malathi, G., Anbazhagan, K., & Kumar, R. S. (2023). Emotion Recognition for Challenged People Facial Appearance in Social using Neural Network. arXiv preprint arXiv:2305.06842.

36. Sugumar, R. (2025). Unified AI Framework for Predictive Data Engineering and Real Time Prescription and Billing Systems. International Journal of Advanced Engineering Science and Information Technology (IJAESIT), 8(5), 17261.

37. Vekariya, V., Kumar, S., & Rengarajan, A. (2024). A distinctive and smart agricultural knowledge-based framework using ontology. In Sustainability in Digital Transformation Era: Driving Innovative & Growth (pp. 207-213). CRC Press.

38. Gopinathan, V. R. (2025). Software engineering practices for AI-driven systems: From development to deployment (MLOps perspective). International Journal of Science, Research and Technology, 8(1), 13493-13500.

39. Mathew, A. R. (2022). Threats and protection on E-sim: a prospective study. Novel Perspectives of Engineering Research, 8, 76-81.

40. Naveena, S., & Kavitha, K. (2025). Gossypium herbaceum: Folium disease identification and classification using Efficient Net-Coordinate Convolutional Neural Network (EcoNet). Engineering Applications of Artificial Intelligence, 152, 110701.

41. Rengarajan, A., Mishra, A., Kulhar, K. S., Shrivastava, V. P., & Alawneh, Y. J. J. (2024, March). Role of Deep Reinforcement Learning in Mitigating Cyber Security Issues: A Review. In International Conference on Renewable Power (pp. 37-48). Singapore: Springer Nature Singapore.

42. Achari, A. P. S. K., & Sugumar, R. (2024, November). Performance analysis and determination of accuracy using machine learning techniques for naive bayes and random forest. In AIP Conference Proceedings (Vol. 3193, No. 1, p. 020199). AIP Publishing LLC.

43. Mathew, A., & Alex, H. (2022). Detect & protect-medical device cybersecurity. Curr. Overview Sci. Technol. Res, 1, 60-68.

44. Sammy, F., Chettier, T., Boyina, V., Shingne, H., Saluja, K., Mali, M., ... & Shobana, A. (2025). Deep Learning-Driven Visual Analytics Framework for Next-Generation Environmental Monitoring. Journal of Applied Science and Technology Trends, 114-122.

45. Anbazhagan, K. (2024). Trustworthy and Adaptive AI Systems for Enterprise Analytics Cybersecurity and Decision Optimization Using API-First and Cloud-Native Architectures. International Journal of Technology, Management and Humanities, 10(03), 65-74.

46. Mathew, A. (2021). Deep reinforcement learning for cybersecurity applications. Int J Comput Sci Mob Compu, 10(12), 32-38.

47. Dhinakaran, D. (2022). Joe Prathap P. M, Selvaraj D, Arul Kumar D and Murugeshwari B," Mining Privacy-Preserving Association Rules based on Parallel Processing in Cloud Computing,". International Journal of Engineering Trends and Technology, 70(3), 284-294.

48. Karthika, K., Anusha, K., Kavitha, K., Harshadha, R., Dharshini, D. S., & Sundhar, N. A. (2025, April). Frequency Reconfigurable Antenna using Advanced Materials: A Study. In 2025 3rd International Conference on Advancements in Electrical, Electronics, Communication, Computing and Automation (ICAECA) (pp. 1-6). IEEE.

49. Thavamani, C., & Rengarajan, A. (2024). Clustering related behaviour of users by the use of partitioning and parallel transaction reduction algorithm. International Journal of Advanced Intelligence Paradigms, 29(2-3), 122-132.

50. Sugumar, R. (2025). Unified AI Framework for Predictive Data Engineering and Real Time Prescription and Billing Systems. International Journal of Advanced Engineering Science and Information Technology (IJAESIT), 8(5), 17261.

51. Soundappan, S. J., & Sugumar, R. (2016). Optimal knowledge extraction technique based on hybridisation of improved artificial bee colony algorithm and cuckoo search algorithm. International Journal of Business Intelligence and Data Mining, 11(4), 338-356.

52. SakthiPreetha, A., Kavitha, K., Karthika, K., & Manohari, R. G. (2025, April). A Novel Metasurface-Embedded Antenna for WBAN Communications. In 2025 3rd International Conference on Advancements in Electrical, Electronics, Communication, Computing and Automation (ICAECA) (pp. 1-4). IEEE.

53. Murugeshwari, B., Selvaraj, D., Sudharson, K., & Radhika, S. (2023). Data Mining with Privacy Protection Using Precise Elliptical Curve Cryptography. Intelligent Automation & Soft Computing, 35(1).

54. Gopinathan, V. R. (2025). Software engineering practices for AI-driven systems: From development to deployment (MLOps perspective). International Journal of Science, Research and Technology, 8(1), 13493-13500.

55. Anbazhagan, K., Kumar, R., Thilagavathy, R., & Anuradha, D. (2024, March). Shortest Job First with Gateway-based Resource Management Strategy for Fog Enabled Cloud Computing. In 2024 4th International Conference on Data Engineering and Communication Systems (ICDECS) (pp. 1-6). IEEE.

56. Kannadhasan, S., Vasuki, S., Kavitha, K., Karthikeyan, P., & Usha, S. G. A. (Eds.). (2025, April). Preface: Role of Artificial Intelligence and IoT in Engineering, Technology & Science [ICRAETS 2024]. In AIP Conference Proceedings (Vol. 3258, No. 1, p. 010001). AIP Publishing LLC.

57. Dhinakaran, D., Prathap, P. J., Selvaraj, D., Kumar, D. A., & Murugeshwari, B. (2022). Mining privacy-preserving association rules based on parallel processing in cloud computing. International Journal of Engineering Trends and Technology, 70(3), 284-294.

Downloads

Published

2026-03-28

How to Cite

Adaptive Inter-Region Attention Network for Multimodal Brain Tumor Analysis. (2026). International Journal of Engineering & Extended Technologies Research (IJEETR), 8(2), 3814-3821. https://doi.org/10.15662/IJEETR.2026.0802387