An Integrated AI-Driven Framework for Predictive and Preventive Maternal Health: A Multi-Domain Approach
DOI:
https://doi.org/10.15662/IJEETR.2026.0802081Keywords:
Machine Learning, Gestational Diabetes Mellitus, Down SyndromeAbstract
Maternal and prenatal healthcare involves complex physiological and clinical factors that require early, accurate, and reliable risk assessment to prevent adverse pregnancy outcomes. Recent advances in Artificial Intelligence (AI) have demonstrated strong potential for supporting predictive maternal healthcare; however, existing approaches are often disease-specific, lack interpretability, and face challenges related to data heterogeneity and privacy. This paper proposes an Integrated AI-Driven Framework for Predictive and Preventive Maternal Health that unifies multimodal data processing, explainable machine learning, and secure clinical deployment. The framework incorporates demographic, clinical, and laboratory data to predict maternal risks such as gestational diabetes mellitus using ensemble-based models enhanced with SHAP-based explainability. A Clinical Decision Support System translates predictions into actionable recommendations. Experimental results on publicly available maternal datasets demonstrate improved predictive performance, achieving an accuracy of 92.6% and an AUC of 0.96. The proposed framework offers a scalable, interpretable, and privacy-aware solution for intelligent maternal healthcare.
References
1. H. Zaky, E. Fthenou, L. Srour, T. Farrell, M. Bashir, N. El Hajj, and T. Alam, “Machine learning based model for the early detection of Gestational Diabetes Mellitus,” BMC Medical Informatics and Decision Making, vol. 25, no. 130, 2025, doi: 10.1186/s12911-025-02947-3.
2. M. A. Urina-Triana, M. A. Piñeres-Melo, M. Mantilla-Morrón, S. Butt-Aziz, L. Galeano-Muñoz, S. Naz, and P. P. Ariza-Colpas, “Machine Learning and AI Approaches for Analyzing Diabetic and Hypertensive Retinopathy in Ocular Images: A Literature Review,” IEEE Access, vol. 12, pp. 54590–54620, 2024, doi: 10.1109/ACCESS.2024.3378277.
3. R. AlSaad, A. Elhenidy, A. Tabassum, N. Odeh, E. AboArqoub, A. Odeh, M. AlTamimi, A. Abd-alrazaq, R. Thomas, M. Bashir, and J. Sheikh, “Artificial Intelligence in Gestational Diabetes Care: A Systematic Review,” Journal of Diabetes Science and Technology, pp. 1–18, 2025, doi: 10.1177/19322968251355967.
4. N. P. Shetty, J. Shetty, V. Hegde, S. D. Dharne, and M. Kv, “A machine learning-based clinical decision support system for effective stratification of gestational diabetes mellitus and management through Ayurveda,” Journal of Ayurveda and Integrative Medicine, vol. 15, no. 101051, 2024, doi: 10.1016/j.jaim.2024.101051.
5. O. Adigun, O. Folasade, Y. Nureni, and R. S. Babatunde, “Classification of Diabetes Types using Machine Learning,” International Journal of Advanced Computer Science and Applications (IJACSA), vol. 13, no. 9, pp. 1–8, Sep. 2022, doi: 10.14569/IJACSA.2022.0130918.
6. Y. Du, A. R. Rafferty, F. M. McAuliffe, L. Wei, and C. Mooney, “An explainable machine learning-based clinical decision support system for prediction of gestational diabetes mellitus,” Scientific Reports, vol. 12, no. 1170, 2022, doi: 10.1038/s41598-022-05112-2.
7. Z. Zhang, L. Yang, W. Han, Y. Wu, L. Zhang, C. Gao, K. Jiang, Y. Liu, and H. Wu, “Machine Learning Prediction Models for Gestational Diabetes Mellitus: Meta-analysis,” Journal of Medical Internet Research, vol. 24, no. 3, e26634, 2022, doi: 10.2196/26634.
8. N. Ali, W. Khan, A. Ahmad, M. M. Masud, H. Adam, and L. A. Ahmed, “Predictive Modeling for the Diagnosis of Gestational Diabetes Mellitus Using Epidemiological Data in the United Arab Emirates,” Information, vol. 13, no. 10, p. 485, 2022, doi: 10.3390/info13100485.
9. N. Wang, H. Guo, Y. Jing, L. Song, H. Chen, M. Wang, L. Gao, L. Huang, Y. Song, B. Sun, W. Cui, and J. Xu, “Development and Validation of Risk Prediction Models for Gestational Diabetes Mellitus Using Four Different Methods,” Metabolites, vol. 12, no. 11, p. 1040, 2022, doi: 10.3390/metabo12111040.
10. Sumathi and S. Meganathan, “Ensemble Classifier Technique to Predict Gestational Diabetes Mellitus (GDM),” Computer Systems Science & Engineering, vol. 41, no. 1, pp. 1–12, 2022, doi: 10.32604/csse.2022.017484.
11. J. Yang, D. Clifton, J. E. Hirst, F. K. Kavvoura, G. Farah, L. Mackillop, and H. Lu, “Machine Learning-Based Risk Stratification for Gestational Diabetes Management,” Sensors, vol. 22, no. 13, p. 4805, Jun. 2022, doi: 10.3390/s22134805.
12. N. G. Nia, E. Kaplanoglu, and A. Nasab, “Evaluation of Artificial Intelligence Techniques in Disease Diagnosis and Prediction,” Discover Artificial Intelligence, vol. 3, no. 5, 2023, doi: 10.1007/s44163-023-00049-5.
13. M. Kulkarni-Khairnar, “Conceptual Study of Garbhini Prameha with Special Reference to Change in Lifestyle,” African Journal of Biological Sciences, vol. 6, no. 10, pp. 6138–6147, 2024, doi: 10.48047/AFJBS.6.10.2024.6138-6147.
14. American Diabetes Association Professional Practice Committee, “Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2024,” Diabetes Care, vol. 47, suppl. 1, pp. S20–S42, 2024, doi: 10.2337/dc24-S002.
15. L. Chen and Y. Zhu, “Gestational Diabetes Mellitus and Subsequent Risks of Diabetes and Cardiovascular Diseases: The Life Course Perspective and Implications of Racial Disparities,” Current Diabetes Reports, vol. 24, no. 11, pp. 244–255, Nov. 2024, doi: 10.1007/s11892-024-01552-4.
16. M. Nankya, A. Mugisa, Y. Usman, A. Upadhyay, and R. Chataut, “Security and Privacy in E-Health Systems: A Review of AI and Machine Learning Techniques,” IEEE Access, vol. 12, pp. 148796–148825, Oct. 2024, doi: 10.1109/ACCESS.2024.3469215.
17. O. Manchadi, F.-E. Ben-Bouazza, and B. Jioudi, “Predictive Maintenance in Healthcare System: A Survey,” IEEE Access, vol. 11, pp. 61313–61346, Jun. 2023, doi: 10.1109/ACCESS.2023.3287490.
18. C.Nagarajan and M.Madheswaran - ‘Stability Analysis of Series Parallel Resonant Converter with Fuzzy Logic Controller Using State Space Techniques’- Taylor &Francis, Electric Power Components and Systems, Vol.39 (8), pp.780-793, May 2011. DOI: 10.1080/15325008.2010.541746
19. C.Nagarajan and M.Madheswaran - ‘Experimental verification and stability state space analysis of CLL-T Series Parallel Resonant Converter’ - Journal of Electrical Engineering, Vol.63 (6), pp.365-372, Dec.2012. DOI: 10.2478/v10187-012-0054-2
20. C.Nagarajan and M.Madheswaran - ‘Performance Analysis of LCL-T Resonant Converter with Fuzzy/PID Using State Space Analysis’- Springer, Electrical Engineering, Vol.93 (3), pp.167-178, September 2011. DOI 10.1007/s00202-011-0203-9
21. S.Tamilselvi, R.Prakash, C.Nagarajan,“Solar System Integrated Smart Grid Utilizing Hybrid Coot-Genetic Algorithm Optimized ANN Controller” Iranian Journal Of Science And Technology-Transactions Of Electrical Engineering, DOI10.1007/s40998-025-00917-z,2025
22. S.Tamilselvi, R.Prakash, C.Nagarajan,“ Adaptive sliding mode control of multilevel grid-connected inverters using reinforcement learning for enhanced LVRT performance” Electric Power Systems Research 253 (2026) 112428, doi.org/10.1016/j.epsr.2025.112428
23. S.Thirunavukkarasu, C. Nagarajan, 2024, “Performance Investigation on OCF and SCF study in BLDC machine using FTANN Controller," Journal of Electrical Engineering And Technology, Volume 20, pages 2675–2688, (2025), doi.org/10.1007/s42835-024-02126-w
24. C. Nagarajan, M.Madheswaran and D.Ramasubramanian- ‘Development of DSP based Robust Control Method for General Resonant Converter Topologies using Transfer Function Model’- Acta Electrotechnica et Informatica Journal , Vol.13 (2), pp.18-31,April-June.2013, DOI: 10.2478/aeei-2013-0025.
25. C.Nagarajan and M.Madheswaran - ‘DSP Based Fuzzy Controller for Series Parallel Resonant converter’- Springer, Frontiers of Electrical and Electronic Engineering, Vol. 7(4), pp. 438-446, Dec.12. DOI 10.1007/s11460-012-0212-0.
26. C.Nagarajan and M.Madheswaran - ‘Experimental Study and steady state stability analysis of CLL-T Series Parallel Resonant Converter with Fuzzy controller using State Space Analysis’- Iranian Journal of Electrical & Electronic Engineering, Vol.8 (3), pp.259-267, September 2012.
27. C.Nagarajan and M.Madheswaran, “Analysis and Simulation of LCL Series Resonant Full Bridge Converter Using PWM Technique with Load Independent Operation” has been presented in ICTES’08, a IEEE / IET International Conference organized by M.G.R.University, Chennai.Vol.no.1, pp.190-195, Dec.2007
28. Suganthi Mullainathan, Ramesh Natarajan, “An SPSS and CNN modelling based quality assessment using ceramic materials and membrane filtration techniques”, Revista Materia (Rio J.) Vol. 30, 2025, DOI: https://doi.org/10.1590/1517-7076-RMAT-2024-0721
29. M Suganthi, N Ramesh, “Treatment of water using natural zeolite as membrane filter”, Journal of Environmental Protection and Ecology, Volume 23, Issue 2, pp: 520-530,2022
30. S. Ahmed, M. S. Kaiser, M. S. Hossain, and K. Andersson, “A Comparative Analysis of LIME and SHAP Interpreters with Explainable ML-Based Diabetes Predictions,” IEEE Access, vol. 13, pp. 37370–37384, Mar. 2025, doi: 10.1109/ACCESS.2024.3422319.
31. R. T. Sousa et al., “Depression and Anxiety Screening for Pregnant Women via Free Conversational Speech in Naturalistic Condition,” IEEE Access, vol. 13, pp. 52149–52163, Mar. 2025, doi: 10.1109/ACCESS.2025.3552659.
32. L. K. Nayak, M. Y. Gebremariam, E. Paljug, and R. L. Gleason Jr., “Fast and Simple Statistical Shape Analysis of Pregnant Women Using Radial Deformation of a Cylindrical Template,” IEEE Access, vol. 12, pp. 20251–20264, Feb. 2024, doi: 10.1109/ACCESS.2023.3342608.
33. L. Li, W. Liu, H. Zhang, Y. Jiang, X. Hu, and R. Liu, “Down Syndrome Prediction Using a Cascaded Machine Learning Framework Designed for Imbalanced and Feature-Correlated Data,” IEEE Access, vol. 7, pp. 97582–97593, Aug. 2019, doi: 10.1109/ACCESS.2019.2929681.
34. Anbazhagan, K. (2025). AI Driven Zero Trust Security Model for Enterprise Data Protection and Intelligent Infrastructure Management. International Journal of Technology, Management and Humanities, 11(03), 101-107.
35. Prabha, P. S., & Rengarajan, A. (2025). ENHANCING CLOUD RESOURCE ALLOCATION WITH VISION TRANSFORMER, DEEP REINFORCEMENT LEARNING, AND IMPROVED SHRIKE OPTIMIZATION ALGORITHM. Corrosion Management ISSN: 1355-5243, 35(2), 233-245.
36. Vimal, V. R., & Banerjee, J. S. (2025). Integrating PSO, GA, and ACO for Optimized ECG Feature Selection and Classification of Cardiac Disorders. SGS-Engineering & Sciences, 1(5).





